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Ferrostatin-1 improves neurological impairment induced by ischemia/reperfusion injury in the spinal cord through ERK1/2/SP1/GPX4

Antioxidant Depletion: In an ironnitrilotriacetic acid rat model of hemochromatosis, renal samples showed increases in reactive intermediates, accompanied by decreased availability of systems that protect against oxidation by iron, such as vitamin E levels, the glutathione system, thiol-specific antioxidants, and superoxide dismutase

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DSIP Structure CAS Number (human DSIP): 62568-57-4 (Note: Different variants may have alternate CAS identifiers) Molecular Formula: CHNO Molecular Weight (average): ~848.8 g/mol Monoisotopic Mass (exact): ~848.3 Da Parent Compound: Delta Sleep-Inducing Peptide (DSIP), a naturally occurring nonapeptide studied for its involvement in sleep-related signaling and neuroendocrine regulation pathways

The noted wide effectiveness in all of these models postulates a quite general wound healing effect (Seiwerth et al., 1997)