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The suppression of the type I IFN response by ROS is due to oxidation of cysteine 147 of murine stimulator of IFN, an ER membrane protein that mediates the IFN response after cytoplasmic DNA sensing 59,133,134

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Reduced glutathione 900 mg Vitamin C (in the form of sodium ascorbate and ascorbic acid) *RDA in Vitamin C: 875%

Cancers 14(19):4870 Bartoszewski R, Brewer JW, Rab A, Crossman DK, Bartoszewska S, Kapoor N et al (2011) The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes