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Cross-viral species recognition by coronavirus-reactive T cells has been well described, with SARS-CoV-2-reactive T cells being reported in samples taken before SARS-CoV-2 circulated in humans

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however, in conditions where there is a high demand for nucleotide production (such as in the case for highly proliferative cells), the nonoxidative part of the pathway can function independently of the oxidative phase to produce ribose 5-phosphate from the glycolytic intermediates fructose 6-phosphate and glyceraldehyde 3-phosphate (figure 7.2)

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