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Direct comparisons with semaglutide or tirzepatide should be interpreted with caution, as no head-to-head trials have been conducted

while those with preclinical obesity could be managed with health counseling and monitoring to mitigate progression

The SARS-CoV-2 infection initiates complex human host-pathogen interactions and alters mitochondrial function with significant disruption of glycolysis/TCA cycle (Warburg effect), affecting several metabolic pathways of amino acid (AA), fatty acid (FA), nucleotide, and antioxidant synthesis 139,140

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In contrast to the CRF-NPY antagonism, central administration of CART activates CRF neurons in the PVN, indicating that CRF may mediate the anorectic effect of CART