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It names four: sodium-glucose cotransporter dysfunction, insulin resistance driving aldosterone activation, inflammation, and lymphatic compromise

Bibliography Arillotta et al., 2023

We used the proportion of patients covered as it is less affected by the length of the grace period compared with time-to-event analyses, and takes not only discontinuation but also reinitiation of treatment into account [31]

For purine synthesis, 5-PRPP is converted into phosphoribosyl--amine (PRA) with the addition of an amide group from glutamine by phosphoribosyl pyrophosphate amidotransferase (PPAT)

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