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The expression mechanisms of PD-L1 in tumors may involve signaling pathways within the TME, such as IFN--induced PD-L1 expression, or activation of oncogenic signaling pathways, including PI3K/AKT and MAPK, to promote PD-L1 expression (90, 91)

doi: 10.1080/07315724.2018.1431160 27 Yalle-VasquezSOsco-RosalesKNieto-GutierrezWBenites-ZapataVPerez-LopezFRAlarcon-RuizCA

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33 Subsequently, the DRCR Protocol V showed that patients with CI-DME and vision of 20/25 or better could be closely monitored until they experienced worsening vision