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Extracts derived from fenugreek seeds have been shown to have significant effects on hormone regulation and reproductive health
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Short-chain fatty acids (SFCAs) like acetate, butyrate and propionate, derived from host microbial fermentation of non-digestible carbohydrates, transduce signals through GPCR to promote anti-inflammatory cytokines (IL-10, IL-18) and Treg responses [198, 199] These SCFAs also suppress pro-inflammatory histone deacetylase (HDAC), NF-B and nitric oxide production, thus diminishing oxidative stress-induced epithelial cell apoptosis, and exerting a protective effect on colonic and cardiac health [199]
Retatrutide may actually improve some metabolic markers that steroids negatively impact, potentially reducing the need for aggressive AI use
TRPV3 is expressed predominantly in the gastrointestinal tract and skin, with lower expression levels in the muscle, reproductive tissues, brain, and endocrine tissues (TRPV3 protein expression summary - The Human Protein Atlas n.d)
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