While some athletes choose to load creatine (taking higher doses over several days), NativePath recommends a consistent, low-dose daily approach
doi: 10.3389/fonc.2022.911043 3 YuYWeiCYueMZhangCWangYWangZ
While NAION can occur in anyone, certain factors increase the risk: Age: Most common in individuals over 50 Disc at risk: A small, crowded optic disc structure Cardiovascular conditions: Hypertension, diabetes, high cholesterol Sleep apnea Smoking In recent years, weve observed an emerging concern: the potential link between NAION and certain medications, particularly GLP-1 drugs used for diabetes and weight loss management
That suggests that lower-dose strategies can still affect metabolic markers, but randomized trials directly comparing labeled titration with microdosing protocols are lacking
Note - if you are using a pre-filled syringe, skip this step