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For the single-cell RNA sequencing analyses, healthy controls were derived from publicly available external datasets rather than controls processed in parallel with our patient samples, which may introduce batch effects
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In this paradigm, aquaporin 8 silencing, which is specifically expressed in IMM, enhances mitochondrial ROS generation and results in mitochondrial depolarization and cell death ( 2 O 2 at higher rates than complex I from mitochondria (Quinlan et al., 2014)
A Cross-Species Atlas of the Dorsal Vagal Complex Reveals Neural Mediators of Cagrilintide's Effects on Energy Balance
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