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10.1016/j.tibs.2017.10.006 Trends Biochem Sci

Muhlhausler BS, Belobrajdic D, Wymond B, Benassi-Evans B

Berberine may also slow gastric motility in some individuals, and since GLP-1 medications already delay stomach emptying, this combination could theoretically increase digestive side effects such as nausea, constipation, or bloating