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PubMed Chang CH, et al
We begin by reviewing your childs medical history, previous therapies, and daily functioning
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Severe cases * Liver transplant (can be life-saving) * Autosomal recessive inheritance * Low ceruloplasmin + high urinary copper * Neuro + liver + psychiatric triad * KayserFleischer rings = classic sign Why it matters If untreated, Wilson disease can be fatal
Our further study showed that chronic hypoxia-induced -syn pathology promoted the hydrolytic metabolism of ceramide and decreased protein phosphatase 2A activity through activation of the hypoxia-inducible factor (HIF)-2/alkaline ceramidase (Acer)2 signaling pathway
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