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This barrier severely restricts drug delivery and prevents potentially effective central nervous system treatments from being used clinically [112]

Physicochemical properties, in vitro release, and long-term stability were assessed

Additionally, for ebselen to become a clinically acceptable radioprotector, there is also a need for establishing its selective radioprotective effects without compromising the tumor radiosensitivity

Contributing factors involve hepatic de novo synthesis of cholesterol, reverse cholesterol transport generating HDL cholesterol [25], and hepatic uptake of intestinal chylomicrons