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P.et al (2005)

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Vascular damage is evident as a loss of tight junction proteins on endothelial cells, an increase of permeability and the detachment of astrocytes and pericytes (Figure 1) Dysregulation contributes to cerebrovascular accidents, generates inflammation, and is linked to neurodegenerative diseases, epilepsies, and neuroinflammatory disorders, including multiple sclerosis (Engelhardt and Ransohoff, 2011