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Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021

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When this occurs, renal cells initially respond with protective mechanisms that center around the phosphorylation of extracellular signal-regulated protein kinases 1 and 2 and the resulting stabilization of both HIF-1 and HIF-2