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demonstrated that blockage of the cannabinoid receptor-1 using CB1 antagonists lowered gut permeability and adipogenesis in obese mice, through normalizing Occludin and ZO-1 expression, whereas CB1 stimulation increased permeability markers both in vivo and in vitro [27]

Alterations in the gut microbiota throughout this time precipitate the onset of chronic disorders such as asthma, allergies, and obesity in both adulthood and childhood (505, 506)

[DOI] [PubMed] [Google Scholar] 29.Sun Z., Zhang S., Chan J.Y., Zhang D.D