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Additionally, primary murine PDAC cell lines (F2453 and F2683) from Kras tm1Dsa : Kras FSF-G12D/+

Stem Cell 33 , 31383151 (2015)

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Because vitamin D increases calcium absorption, taking very high doses can contribute to constipation in some people. The Mayo Clinic recommends the following doses: 6 to 15 mg of vitamin A 600 IU of vitamin D 8 to 10 mg of vitamin E 90 to 120 mcg of vitamin K (this is the recommended daily intake, which most people get from their diets) 4