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Understanding these potential mechanisms helps clinicians counsel patients appropriately and distinguish between expected treatment effects and concerning adverse reactions

Side effect profiles are largely similar between oral and injectable semaglutide, with fewer than 10% of patients discontinuing due to adverse effects

Glucagon signaling may influence energy expenditure and liver-related metabolism

Common issues include nausea and diarrhea, but complications can also extend to conditions such as gastroesophageal reflux disease, gastroparesis (paralysis of the stomach), and colonic inflammation

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