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*Correspondence: Tione Buranda, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This indicates that safety signals are more visible in pooled short-term RCTs, while long-term adherence and the risks of weight rebound or metabolic withdrawal post-discontinuation remain difficult to quantify reliably in existing studies