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Notably, conditional STK11/LKB1 knockout mice have been shown to develop atypical hyperplasia and prostatic intraepithelial neoplasia (Pearson et al., 2008)

A., Harish, Varjani, S., Singh, G., Marchand, J., Schoefs, B., & Vinayak, V

Shorter-term (7 days) L-citrulline malate supplementation has been shown to augment skeletal muscle power output due to a greater oxidative energy turnover and a lower pH-to-power ratio [12]

SP@M increases LC3-mediated autophagy as well as strengthens ubiquitin-mediated proteasomal degradation toward KEAP1, which promotes the expression and nuclear translocation of NRF2

Furthermore, KD treatment has been suggested to influence the deposition of both A and tau, potentially slowing the progression of the underlying pathology [103, 104]