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Seek medical advice if you experience: Unintentional weight changes (loss or gain of more than 5% body weight over 3-6 months without dietary or activity changes) Persistent fatigue that doesn't improve with rest and affects daily functioning Heat or cold intolerance that differs significantly from your usual tolerance Cardiac symptoms including palpitations, irregular heartbeat, or chest discomfort Tremor, anxiety, or agitation that appears without clear psychological triggers Changes in bowel habits , particularly persistent diarrhoea or constipation Menstrual irregularities or fertility concerns potentially related to metabolic dysfunction Mood changes , including depression or anxiety, especially if accompanied by physical symptoms Seek urgent same-day medical attention for: Severe palpitations or irregular heartbeat Fever with confusion or agitation (possible thyroid storm) Severe headache with palpitations and excessive sweating (possible phaeochromocytoma crisis) Sudden onset of jaundice or severe abdominal pain while taking antithyroid medication Your GP will conduct a thorough clinical assessment including medical history, physical examination, and appropriate investigations
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