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Multiple variants across multiple pathways means you can be debilitated by exposures that others around you do not notice

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Brigelius-Flohe R, Maiorino M

Glutathionylation of the active site cysteine, a prerequisite for enzymatic activity, occurs only under highly oxidizing conditions established by the GSH/glutathione disulfide (GSSG) redox couple, while class I GRXs are readily glutathionylated even at very negative GSH/GSSG redox potentials

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