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NCD dog breeds, especially large breeds, can also develop IVD disease (mainly Hansen type II herniation), but in the caudal cervical (C5-T1) or lumbosacral (L6-S1) spine at about 68 years of age, mostly due to trauma or wear and tear [5, 9]

35 The role of histones as damage-associated molecular patterns (DAMPs) can trigger toll-like receptors (TLRs), activate the NLRP3 inflammasome, and induce calcium influx, leading to the initiation of inflammation in conditions, such as acute pancreatitis