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The anxiety level was assessed based on the animals' activity in the central arena, which is a highly anxiety-producing environment

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This is considered to be the rate limiting step because it is dependent on the bioavailability of cysteine and the activity of GCL, the latter of which is modified by competitive inhibition by reduced glutathione (GSH) [3134]

Glutathione, an Antioxidant Tripeptide: Dual Roles in Carcinogenesis and Chemoprevention

To help reduce any gastrointestinal side effects, your physician will increase your dose gradually over the course of 16 to 20 weeks