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Medical weight loss options include Retatrutide, Tirzepatide, and Semaglutide, while compounded peptide therapies include NAD+, Tesamorelin, and Sermorelin

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Compared with conventional GLP-1 receptor agonists, such as liraglutide and semaglutide, tirzepatide has demonstrated superior efficacy in body weight control in several phase III clinical trials, with average weight reductions exceeding 20% in some study populations (15)

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The FTO rs9939609 variant correlates with baseline metabolic rate and fat accumulation tendency