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Results vary based on where youre starting from
A randomized controlled trial on the effect of metformin in CHD patients without diabetes showed that it (2000 mg/day, P.O for 12 months) not only decreased oxidative stress but also lowered left ventricular mass (LVM) and improved blood pressure [227]
For example, they might use 2.4 mg for 12 weeks, then reduce to 1.0 mg for 4 weeks, then return to 2.4 mg
In the ATTAIN-1 phase 3 trial (NCT05869903), adults with obesity who received orforglipron 36 mg once daily achieved a mean body weight reduction of 12.4% (approximately 27.3 lb) from baseline at 72 weeks, compared with 0.9% in the placebo group
Some people feel slightly more tired, while others feel no change at all
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