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Biotechnol Prog 20:449456 Drge W, Breitkreutz R (2000) Glutathione and immune function

The post reports headache incidence of 5 to 8 percent in treatment arms versus 4 to 6 percent in placebo groups, which it calls a modest but meaningful difference

The primary solvents, PG and VG, act as carriers for nicotine and flavorings, but when exposed to high temperatures, they decompose into reactive carbonyl compounds such as formaldehyde and acrolein, both of which are highly cytotoxic to hepatocytes [120, 121]