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Taking it with food or other liquids drastically reduces absorption

PDE-5i, phosphodiesterase-5 inhibitor

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Signal Transduction and Redox Signaling : Investigates S-glutathionylation and how it can change enzyme activity and transcriptional control

Hypoglycemia: Although not as prevalent, hypoglycemia, or low blood sugar, can happen when this is taken with other diabetes medications that also lower blood sugar