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Leydig cell aging (Zhang et al., 2020, Aging) FOXO4-DRI improved testosterone secretion and the testicular microenvironment in aged mice by clearing senescent Leydig cells

Substantial evidence has shown that renal fibrosis is linked to hyperactive pro-fibrotic molecular players, such as the renin-angiotensin system (RAS), reactive oxygen species (ROS), Toll-like receptor 4 (TLR4), and aryl hydrocarbon receptor (AHR) [22-25]

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In addition, SA--gal highly expressed, together with elevated expression of p53 and progerin in cell nuclei in the CCl 4 group and the CCl 4 + LV-CTR group on Day 6 and Day 28