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Specifically, a threefold increase in neutrophil count, a twofold increase in protease levels, and 2-4 times higher levels of IL-8, IL-6, IL1, and leukotriene B4 have been observed in the epithelial lining fluid compared to healthy controls (50)

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This is usually an indication that you have a methylation defect and need to slow down on the amount of B12 you are taking