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High-density lipoprotein cholesterol (HDL-C) changes are variable and generally minimal, with some studies showing slight increases and others showing no significant change

In the LOOK-AHEAD study, 5145 participants aged 4576 years (mean BMI 36 kg/m 2 ) with T2D were randomized to either calorie restriction or diabetes support and education intervention (controls) [33]

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Miners JS, Barua N, Kehoe PG, Gill S, Love S