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Tanei S, Miwa M, Yoshida M et al (2020) The method simulating spontaneous pain in patients with nociplastic pain using rats with fibromyalgia-like condition

Activation of the GLP-1 receptor in microglia, GABAergic interneurons and astrocytes stimulates several intracellular pathways including the PI3K/Akt, cAMP/PKA/CREB, and P-Akt/p-eNOS and subsequently confers neuroprotective effects through inhibition of gp91/CHOP, Nrf2/HO-1, Bax/Bcl-2/caspase3/PARP, NF-B/ICAM-1, and JAK2/STAT3

Under oxidative stress, Trx separates from ASK1, activating ASK1

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