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In another aspect, the present invention provides use of tirzepatide for the manufacture of a medicament for improving glycemic control in a subject having type 2 diabetes (T2D) and being treated with a 20 mg dose of tirzepatide once weekly for at least four weeks, but in need of additional glycemic control, comprising: increasing the dose of tirzepatide being administered to 25 mg once weekly

Tolerance profiles were favorable: transient nausea (2025%), diarrhea (1015%), and very low rates of severe hypoglycemia

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By stimulating insulin release and suppressing glucagon secretion (a hormone released by the liver that increases glucose in the bloodstream), GLP-1s contribute to reduced blood sugar levels

Rotate to a new injection site each week to allow tissue recovery and maintain consistent drug levels