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Cardiac protection via metabolic modulation: an emerging role for incretin-based therapies

Death from a cardiovascular event, nonfatal myocardial infarction (heart attack), or nonfatal stroke occurred during the trial in 6.5% of patients who were treated with semaglutide versus 8.0% of patients who received placebo a 20% reduction in relative risk by semaglutide

the clinical significance of reducing IGFBP engagement through synthetic analogues is not yet resolved [9]

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Significant results (8-10% loss) become evident around week 12 as you reach therapeutic doses