We propose that hepatic activation of TH signaling has insulinotropic and glucose-lowering effects, as it is able to increase non-12-OH FXR-antagonistic BA levels through shaping the BA composition by repressing hepatic CYP8B1, thereby enhancing the GLP-1 production via suppressing intestinal FXR signaling
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Specifically, these structures are termed circumventricular organs, and act to receive signals from circulation, like angiotensin II (Ang II), nitric oxide (NO), atrial natriuretic peptide (ANP), vasopressin (AVP), and endothelin
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