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Pioneer 1: Randomized clinical trial of the efficacy and safety of oral semaglutide monotherapy in comparison with placebo in patients with type 2 diabetes

This preparatory phase helps patients build habits such as slowing down during meals, emphasizing protein first, reducing sugary drinks, and maintaining hydration

Since GLP-1 constipation is caused directly by the medication slowing gastric and intestinal motility, bowel function typically returns to baseline within 1-2 weeks of discontinuation

310 GIP is not as potent as GLP-1 and has a longer half-life of ~5 minutes, but it is also inactivated by DPP-IV enzymes in circulation

Patches are hands-free