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Desbonnet et al., 2015)

(PubMed) Bryan J, Calvaresi E, Hughes D

Moreover, melancholic depression is marked by elevated KYN/TRP ratios [48], and KYNA/QA ratios inversely correlate with anhedonia severity [49]

In 28-month-old mice, roughly equivalent to elderly humans, three weeks of GHK-Cu administration produced significantly faster maze navigation with evidence of decreased brain inflammation and increased histone deacetylase 2 labeling, an indicator of epigenetic pathway activation