The MDA levels of the CYP groups were significantly ( P 0.05) greater than those of the controls
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Dietary intake of fatty acids and fish in relation to cognitive performance at middle age
This multidimensional, target-specific strategy holds promise for enhancing therapeutic efficacy while minimizing systemic side effects.Future large-scale longitudinal randomized controlled trials should prioritize structural and functional endpointssuch as TEWL, AMP expression, and tissue remodeling markerswhile incorporating refined stratification variables, including VDR polymorphisms, metabolic-nutritional status, and biological aging indices, to identify responsive subpopulations, optimize dosage windows, and enhance intervention efficacy
Because age-related cognitive decline has been linked to free radical-induced oxidative damage in the brain (159, 160), antioxidant supplements might help protect against cognitive aging
