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Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro

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Materialien und Methoden In jeder Ratte wurden zwei sterile Schwmme (1 cm 1 cm 0,25 cm (V = 0,25 ml)) mit den gleichen Mengen an NaBPC157 (Lsung 50 g, 10 g, 10 ng/ml) oder den Referenzmitteln, Cimetidin (10 mg, 100 mg, 500 mg/ml), Ranitidin (2,5 mg, 25 mg, 250 mg/ml), Famotidin (10 mg, 50 mg, 100 mg/ml) und Sucralfat (1 mg, 5 mg, 10 mg/ml), subkutan in der Lumbalregion implantiert