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Any studies that do exist tend to be small

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One form of vitamin E, gamma-tocopherol, was found to increase blood flow by promoting the dilation of blood vessels, potentially reducing blood pressure and the risk of heart disease ( Gamma-tocopherol supplements may also have a blood-thinning effect as well as a reduction effect on LDL (bad) cholesterol levels ( In contrast, other studies suggest that high dose vitamin E supplements may be harmful, even when they dont cause any obvious symptoms of toxicity

The MTHFR enzyme is thermolabile (deactivated by heat) and its activity may be further reduced in individuals with polymorphisms as environmental temperatures rise due to global warming exacerbated by air pollution

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