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Expansion into Chronic Weight Management: November 2023 While many people used tirzepatide off-label for weight loss throughout 2022 and early 2023, the next major milestone occurred in late 2023

HbA 1c was reduced in SURPASS 15, using from 5 to 15 mg of TZP per week, by between 1.69 to 2.58%, and a new plateau of HbA 1c and fasting serum glucose (FSG) was reached with approximately 2430 weeks of treatment

Clearly, distinct sequence and structural features of tirzepatide and peptide 20 allow them to exert combinatorial agonism at two or more receptors at the same time thereby maximize the benefit of polypharmacology and minimize the limitation of mono-targeting

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