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The identification of genes which overexpression contributes to intellectual disability (ID) in DS is important to understand the pathophysiological mechanisms involved and develop new pharmacological therapies

doi: 10.7150/ijbs.85467, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 128

Horton JD, Shimano H, Hamilton RL, Brown MS, Goldstein JL (1999) Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

Plenty of nonsteroidal anti-inflammatory drugs (NSAIDs) were recruited in many clinical trials for AD treatment (122)