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Moloney AM, Griffin RJ, Timmons S et al (2010) Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimers disease indicate possible resistance to IGF-1 and insulin signalling

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Prior treatment : Participation in a comprehensive weight management program that includes behavioral modification, reduced-calorie diet, and increased physical activity for at least 6 months before starting weight loss injeciton therapy