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These cells are some of the largest neurons in the human brain, with an intricately elaborate dendritic arbor, characterized by a large number of dendritic spines

Increased HIF-1 activity is well documented in several cancers, including melanoma [68]

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LRRK2 mutations (such as G2019S) promote mitochondrial fission in microglia by enhancing kinase activity, releasing mtROS and other factors to activate the NLRP3 inflammasome, exacerbating neuroinflammation in PD, and their regulation of mitochondrial dynamics has potential associations with ferroptosis (124)