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Tirzepatide is typically administered in slightly larger doses compared to semaglutide, but both are taken once weekly

The Aib (2aminoisobutyric acid) residue at the Nterminus improves resistance to enzymatic degradation, while modified amino acids such as D2naphthylalanine and Dphenylalanine enhance laboratory stability

Those who received the semaglutide lost close to 15 percent of their body weight, on average, compared to 2.4 percent among those receiving the placebo

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