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Generic manufacturers who attempted to replicate the abuse-deterrent properties through alternative polymers were unable to secure FDAs abuse-deterrent labeling, which meant their label explicitly disclaimed the deterrent properties that Purdue claimed a commercial disadvantage that depressed their market share even after launch

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They typically occur during the first 1-2 weeks of starting the medication

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[DOI] [PMC free article] [PubMed] [Google Scholar] [69].Cuzzocrea S, De Sarro G, Costantino G, Ciliberto G, Mazzon E, De Sarro A, et al