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Critical unresolved issues include identifying the molecular switches that govern the transition of autophagy from an anti- to a pro-ferroptotic state, elucidating subtype-specific differences in crosstalk mechanisms, and clarifying the molecular basis underlying proteins such as COX7A1 to exhibit opposing functions

Other research has indicated that copper deficiency inhibits the expression of adhesion molecules, while activating endothelial cells through inducing leukocyte adhesion (105)

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