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Given that retatrutide is currently only available within clinical trials, all participants should have direct access to a trial medical team for any concerns relating to dosing or side effects

Insulin, induced by feeding, stimulates TGF-1 expression in adipocytes, activating the TGF--SMAD3 pathway

This is corroborated by setmelanotides clinical trials, where participants with monogenic obesity or HO respond more strongly to treatment than general obese participants (NCT02041195, NCT01749137) (75, 77, 79, 87, 9094)

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