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Genome and biochemical analyses of pathogenic and commensal species revealed that all Neisseria species have a highly conserved nitric oxide reductase (NorB) and nitrite reductase (AniA or NirK), while only Neisseria mucosa contained a nitrate reductase (Nar), and only Neisseria lactamica , Neisseria cinerea , Neisseria subflava , Neisseria flavescens , and Neisseria sicca contained a nitrous oxide reductase (Nos) complex ( Neisseria species is the lack of a functional Nos system in the pathogenic species N

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However, the hydrophobicity of aryl OPFRs makes this a highly likely possibility [231, 258, 259]

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