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The new tissue that forms appears more organized and structurally sound compared to natural healing without intervention

The discomfort can vary in intensity, with some people describing it as mild and others finding it debilitating

A change in the ratio of reduced glutathione to oxidized glutathione can indicate a negative shift in cellular health

461 These neurons also demonstrate increased spontaneous activity independent of ascending afferent input and possess enlarged receptive fields, suggesting that thalamic neurons function as central generators or amplifiers of pain in DPN