Discussion While GLP-1 RAs are powerful anti-obesity medications (AOMs), they do raise some serious concerns most notably, up to 40% of the profound weight loss induced by these agents can be due to loss of lean mass 3,4,5 and prior studies have shown that a significant portion of this lean mass is muscle 33,34,35
Last reviewed: June 30, 2026 Last updated: June 30, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
Once activated, several beneficial processes begin: Appetite signals to the brain increase: GLP-1 communicates with appetite centers in the brain, particularly areas involved in satiety regulation
If you swallow the drops immediately, the medication will pass through your digestive system, where stomach acid can degrade it
Edens $249 tirzepatide requires a three-month upfront prepayment